![]() This antibody-antigen complex moves via capillary flow to a test area which then identifies a positive test by the presence of a coloured line. They work by binding of conjugated antibodies to a specific antigen in a sample. Lateral flow device (LFD) immunoassays are common, inexpensive, readily available testing devices that are used in the detection of a number of different medical conditions. Potentially, LFDs could support the scaling up of mass testing to aid track and trace methodology and break the chain of transmission of COVID-19 with the additional benefit of providing individuals with the results in a much shorter time frame. Test performance does not appear dependent on the operator. Some perform with high specificity but a great range of sensitivities were shown (38.32–99.19%). This systematic review identified that the performance of lateral flow devices is heterogeneous and dependent on the manufacturer. Operation of the test by a trained professional or by the test subject with self-swabbing produced comparable results. Twenty-four papers were identified involving over 26,000 test results. Data was pooled based on manufacturer of LFD and split based on operator (self-swab or by trained professional) and sensitivity and specificity data were calculated. Based on extracted data sensitivity and specificity was calculated for each study. MethodsĪ targeted search of Pubmed and Medxriv, using PRISMA principles, was conducted identifying clinical studies assessing the sensitivity and specificity of LFDs as their primary outcome compared to reverse transcriptase polymerase chain reaction (RT-PCR) for the detection of SARS-CoV-2. Our aims were to assess the sensitivity and specificity of LFDs in a systematic review and summarise the sensitivity and specificity of these tests. There are now several studies assessing their accuracy but as yet no systematic review. They have been advocated for use by the World Health Organisation to help control outbreaks and break the chain of transmission of COVID-19 infections. This product cannot be purchased by under 18s.Lateral flow devices (LFDs) are viral antigen tests for the detection of SARS-CoV-2 that produce a rapid result, are inexpensive and easy to operate. A certificate will not be issued for tests taken outside the app and you will need to purchase another one at your own cost. Once logged in, you will be shown step-by-step instructions, including when to take the test. You must complete the test procedure using the Certific App. Easy, reliable and fast Verification Method.Complete CE marked sample collection kit that includes: Swab, Test Cassette, Extraction Tube, Extraction Buffer Sachet, Manufacturer’s Instructions for Use.More detail on delivery times available here. Get your result certificate in 60 minutes during business hours (Certific’s business hours are Monday-Sunday 8:00 to 22:00, UK time).Rapid pre-departure COVID-19 test for travellers flying to destinations accepting lateral flow antigen test results for Fit to Fly certificates.Quick and easy self-test with digital results. Affordable home Lateral Flow (Antigen) Home Testing Kit.
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